Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial

Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04419-1

In an interim analysis of a phase 1/2 trial in 24 patients with newly diagnosed glioblastoma, a genetically engineered autologous stem cell transplant designed to deliver interferon-α to the tumor microenvironment was well tolerated, with stable engraftment and evidence for immune reprogramming.

Source: www.nature.com