Data-driven prioritization of high-risk individuals for weight loss interventions

Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04353-2

OBSCORE is a machine learning-based risk prediction tool that uses a set of clinical features to stratify individuals with a body mass index (BMI) of ≥ 27 kg m−2 by their 10-year risk of obesity-related complications, outperforming existing models. OBSCORE is generalizable across diverse populations, supporting risk-based prioritization of obesity interventions that goes beyond simple BMI thresholds.

Source: www.nature.com