Early kidney risk prediction in <i>APOL1</i> high-risk genotype carriers

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04343-4

A nine-protein plasma signature is predictive of kidney events and mortality in individuals with a high-risk APOL1 genotype and preserved estimated glomerular filtration rate, outperforming existing clinical and genetic risk tools and providing a biologically plausible marker set for early intervention and trial enrichment.

Source: www.nature.com